Pope Francis suffered an “isolated” respiratory crisis on Friday while receiving treatment for double pneumonia at Rome’s Gemelli hospital, according to Vatican officials. The 88-year-old pontiff experienced a bronchial spasm that required mechanical ventilation assistance, though he remained conscious throughout the episode and responded positively to medical intervention.

This development represents a setback following two days of encouraging health updates. In response, the Vatican has modified his schedule, with Cardinal Angelo De Donatis stepping in to fulfill the pontiff’s Ash Wednesday responsibilities.

Although his condition is currently stable, there are ongoing concerns regarding his ability to preside over the upcoming Holy Week and Easter celebrations. Catholics around the world continue offering prayers for the Pope’s recovery.